BYU is about 30 miles south of here in Provo and my lab at BYU is a metabolism research lab. His name is Linus Dome. He is a must-follow on social media: Twitter: @BenBikmanPHd; Instagram: @BenBikmanPHd No. I once tried a two-day fast and I just did not enjoy it. And there are general reference ranges, but it is a separate beast entirely, for reasons that I confess I don’t know, something about the biochemistry of the molecule itself; it requires a totally separate vial of blood. Bret:  Or if you’re already diabetic or if you need more rapid weight loss then the ketosis will probably be beneficial faster. Glycolysis gene expression, not at all. And they know that mom and dad are healthy and fit and some other moms and dads aren’t. It’s about my relationship with my wife, my relationship with my children, that is priority number one. Ben:  Yeah, but you can understand. I was enthusiastic about it as well. Otherwise, leave me alone. One of the hardest parts of starting a keto diet is figuring out what to eat. You said it perfectly and George Cahill was the first researcher from decades ago who really looked at starvation and a lot of insulin. Ben:  That’s because protein is known to activate mTOR and mTOR is known to inhibit autophagy. Is it just lowering the carbohydrates that give a lot of the benefits of a low-carb diet or is it actually the ketones themselves having an active role in our body and playing a beneficial role? Bret:  And they’re going to get it at their friend’s house, they’re going to get it at their grandma’s house or at their uncle’s house. Ben:  Well if I did, I stole it from Gary Taubes, who had an article that he called Prosperity’s Plague. Show me where I’m wrong.”. Can a keto diet help with chronic pain like fibromyalgia, migraines or arthritis? You can say whatever you want to me. But I just want them to focus on the positive. And I can say that there is a guy writing and trying to copy George Cahill… but he mentioned insulin as the fed hormone like you said, the hormone indicative of the fed state, but also the hormone that generally directs metabolism. And you know when Prof. Bikman says something, you know it based on research, you know it’s based on science. So short of having that test, what are some other markers people can use to try and help them determine if they can handle a certain amount of protein without worrying about gluconeogenesis, without worrying about their insulin to glucagon ratios? JavaScript must be enabled in your browser to log in! May 11, 2017 RJacoby Dr. J Recommends, Media diabetes, Dr. Benjamin Binman, insulin, insulin resistance, ketogenic diet, ketones Dr. Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders. Bret:  That makes sense, but there’s a lot of that out there, isn’t there? Bret:  It has to be sort of disconcerting to say this is what all the textbooks say, this is what the guidelines say, but as an academic I want to see the primary research. It’s glorious. 49:00  A day in the life of Ben Bikman I know when we do what’s called multiplex assays, we can measure or multi-analyte, we could measure insulin, leptin, cortisol, growth hormone all in one little batch of plasma from blood. Definitely, and Stephen Thompson did it. And I love putting eggs in shakes, just rocky style kind of shakes. It is little pepperonis, it is cheese sticks, vegetable platter with some non-seed oil ranch dip, you now. Dr. Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders. Now, someone might say to me, Ben, you need to give it a few more hours and you’ll get into that true kind of long running state. In humans of course we don’t have any evidence to confirm that, but that’s a lot of the rationale behind the caloric restriction studies. that you just don’t really find. I’ve been feeding them bacon and eggs for years. Now like I said earlier according to Roger Unger’s work from decades ago– and in this is changed of course because we have higher sensitivity tests to determine insulin and glucagon now, but if I remember correctly the fasted insulin to glucagon ratio is around 1.5. Ben:  Yes, especially to the point of diagnosed hyperglycemia. And yet there’s a downside of course to hyperinsulinemia or when insulin is getting too high for too long. That kind of challenges the whole longevity paradigm with protein being the villain. And that’s just something I’m very mindful of. When is this low-carb good enough and when do I need to be in ketosis? Why is insulin so important for us to control and why does a ketogenic diet help so many people? Bret:  Right, I think that’s an important point and it’s kind of hard to bring up in a politically correct way, to say look at us and look at some of your friends’ parents and compare us. At 30 minutes – the leucine treatment down, mTOR is gone. It’s don’t count your calories; eat as much as you can until you’re full and then you’re done. The ketones provide, you know– 80 % of the benefit of low-carb is from insulin control. Dr Benjamin Bikman. And sure enough, if the brain can’t use glucose, there’s only one other fuel, that’s the ketone. Are you confused about what a plate of keto food should look like? Dr David Jockers is passionate about seeing people reach their health potential in mind, body and spirit. So it was pretty interesting to me this idea of what I like to call a nutritional fast, rather than a caloric fast. Love Ben Bikman! Diet Doctor Podcast #35 with Ben Bikman, PhD. Learn more about Dr. Bikman. Bret:  I want to get into all the specifics–. But it is interesting to know the difference. Dr. Ted Naiman is one of the individuals who believes more protein is better and recommends a higher intake. So nevertheless insulin very much controls autophagy. Think about an ischemic hypoxic heart; there’s less oxygen and it can maintain ATP production. They both went up; leucine and mTOR exposure to the muscle cells. Prof. Ben Bikman thank you so much for joining me on the Diet Doctor podcast. That’s fine because it’s protein that inhibits autophagy. And looking at that point me… forcing myself to say… okay what is the best way to address insulin resistance? People that were getting hundreds and hundreds if not over 1000 calories per day in oils added to their drinks and I thought that is not healthy. Dr. Ron Rosedale at Low Carb Vail 2016. And not about anything beneficial. Exploiting cancer metabolism with ketosis. I’m terrified of somehow contributing to someone’s eating disorder. Dr. Ron Krauss helps us understand the nuances beyond LDL-C and how we can use all the available data to help us better understand what we know and do not know about cholesterol. Maybe not an outright malicious lie, but much of what “we” believe in medicine can be traced back to word-of-mouth teachings without a scientific basis. This is what I want this healthy strong body, for me, daddy, mommy wants a healthy strong body, we are trying to do this by eating these kinds of things. So I rage against that idea and I really hope in fact the very students, or anyone who’s claiming that’s an advocate of a low-carb diet– mind you, when I’m in professor mode, I’m not advocating anything, I’m just showing the data. Cooking keto with Dr. Èvelyne Bourdua-Roy. I cannot begin to explain how great Dr. Bikman is at explaining the differences between brown and white fat, what metabolism is, how calories do … After watching the podcast interview above, you’ll undoubtedly realize he is a force of knowledge in the world of insulin, type-II diabetes, metabolic disease, and using a low-carb or ketogenic diet to combat them. Now one last comment about glucagon, as people are getting introduced to that perhaps for the first time, there is a phenomenon I almost hate to bring this up called glucagon resistance and that could be instances of– when people have had liver damage like a hepatitis, like an actual infection. We make a ranch dip out of ranch seasoning in whole fat Greek yogurt, or sour cream, my wife does that. There’s mobilization of fat, there’s activation of autophagy, even though they’re not in fact hungry, not fasting. So they’re more rigorous, if you will, more resistant to insults. Part 1 of eating keto with Kristie: Introduction.
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